Got any tips or tricks for long distance driving with a newborn?

My husband and I are going to be traveling with our 2 sons (18 months and 3 week old) from Illinois to Maine by car. I wanted to know if there are any tips/tricks to traveling that long with a newborn, whether or not I should sit in the back with them, etc. I know there are going to be frequent stops for diaper changes and feeding. We also know its going to take 3 or 4 days or so to get there. Any tips would be greatly appreciated!

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